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Event ID: 10003 Source: MSExchangeTransport

The transport process failed during message processing with the following call stack: System.AccessViolationException: Attempted to read or write protected memory. This is often an indication that other memory is corrupt.
Microsoft.Exchange.Security.Cryptography.CapiNativeMethods.CertGetCertificateChain(S afeChainEngineHandle engine, IntPtr pCertContext, IntPtr time, SafeCertStoreHandle hAdditionalStore, CertChainParameter& parameters, ChainBuildOptions flags, IntPtr reserved, SafeChainContextHandle& chainContext)
Microsoft.Exchange.Security.Cryptography.X509Certificates.ChainEngine.BuildAsAnonymo us(X509Certificate2 certificate, ChainBuildOptions options, ChainBuildParameter parameter)
Microsoft.Exchange.Protocols.Smtp.CertificateValidator.ChainValidateInternal(String domain, X509Certificate2 cert, Boolean validateAsAnonymous)
Microsoft.Exchange.Protocols.Smtp.CertificateValidator.ChainValidateAsAnonymous(X509 Certificate2 cert)
Microsoft.Exchange.Protocols.Smtp.SmtpOutSession.TlsNegotiationComplete(IAsyncResult asyncResult)
Microsoft.Exchange.Net.LazyAsyncResult.Complete(IntPtr userToken)
Microsoft.Exchange.Net.NetworkConnection.InvokeSendCallback(LazyAsyncResultWithTimeo ut asyncResult, Object result)
Microsoft.Exchange.Net.NetworkConnection.SendTlsNegotiationCompleted(IAsyncResult asyncResult)
at System.Net.LazyAsyncResult.Complete(IntPtr userToken)
at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state)
at System.Net.ContextAwareResult.Complete(IntPtr userToken)
at System.Net.LazyAsyncResult.ProtectedInvokeCallback(Object result, IntPtr userToken)
at System.Net.Sockets.BaseOverlappedAsyncResult.CompletionPortCallback(UInt32 errorCode, UInt32 numBytes, NativeOverlapped* nativeOverlapped)
at System.Threading._IOCompletionCallback.PerformIOCompletionCallback(UInt32 errorCode, UInt32 numBytes, NativeOverlapped* pOVERLAP)
If you just installed Exchange 2010 SP3 Update Rollup 1 see the 'Known Issue' on ME2803727. Basically it tells you to disable any transport rule that adds a disclaimer to outgoing emails then you can resume emails that are in the Poison Message queues on your CAS servers. That's the workaround as MS doesn't have a solution yet.
Applies to Exchange 2008 - This error event indicates that the transport process failed during a message processing operation. To resolve this problem install Update Rollup 2 for Exchange Server 2007 Service Pack 1. See ME947551.
ME957002 indicates that this error may occur on a Microsoft Exchange Server 2007 Service Pack 1 (SP1) Edge server, when you use a Send connector that uses the BasicAuthRequireTLS value. To resolve this problem, install Update Rollup 2 for Exchange Server 2007 Service Pack 1.

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