This problem started after applying KB890175, KB891711, and KB871250 on a Windows 2000 SP4 server that is a DC running Exchange 2000 (SP3) and McAfee GroupShield for Exchange 5.2. Restarting the GroupShield service didn't fix the problem. The event log began filling up with event ID 1048 and the message "McAfee GroupShield Exchange failed to send message", when a new email that contained a virus came in. Virus scanning worked GroupShield just couldn't notify. A full reboot of the server fixed it.
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