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Event ID: 12801 Source: MSExchangeIS

Message processing failed because there is not enough available disk space (8004010D-82000374)
This issue could occur when you have got issue on SAN. In this case you have to restart related SAN port, and afterthat also cluster node.  After this action will be issue fixed.
This event occurs even when aparently there is enough space on all hard drives.
From a newsgroup post: "This has happened to me once when I re-checked the free space I realized the 5 gig free was actually 5K". This may indicate that while the disk may appear to have enough space, in reality, due to fragmentation or size of the allocation unit on the disk, the usable space may not be enough. I suggest doing  a chkdsk and a defragmentation.

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