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Event ID: 1377 Source: NTDSInter-site

Level
Description
The initialization of transport CN=SMTP,CN=Inter-Site Transports, CN=Sites, CN=Configuration, DC=<domain name>, DC=<top-level domain> (with transport DLL ismsmtp.dll) failed with the following status:
The specified module could not be found.
The record data is the status code.
Comments
 
Inter-site messaging service failed to start. This service is really unlikely to fail starting without having other bigger problems on the DC. Check what else is going wrong and then this problem will be solved.

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