In my case I got: Download of virus definition file from LiveUpdate Server failed. 00000001
This is occuring on a SSC server that is pointing to an upstream LiveUpdate Administrator server. LiveUpdate (VPDN_LU.exe) when run manually reports that it 'could not find an update file on the server'.
Download of virus definition file from LiveUpdate server failed. 00000001
Found the issue was with the Live Update configuration. If you aren't using a proxy when connecting to the internet ensure the FTP and HTTP options in the Live Update Configuration (Control Panel > LiveUpdate Configuration) is set to not use a proxy server for HTTP/FTP.
Push out an update from the SAV server and the client will update.
When a secondary Symantec AntiVirus Server receives virus definitions from the Parent Server, this event appears in the Event Viewer of the Secondary Server.