From a Citrix support forum: "The error refers to a connection failure between the PS server and the Database server on which the Datastore resides.
In a multi server enviroment it is recommended that you have the datastore on a seperate database server and all PS servers communicate to it directly.
Also your error refers to [b]indirect:0[/b], i assume this error is occurring on a server which is indirectly connected via a PS datacollector server to the Database server. The contents of the file MF20.dsn would tell you the type and where the database resides."
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There could be a few different reasons for this type of problem.
Make sure your Datastore is on a reliable and accessible server. The "reboot fixed my issued" mentioned tends to indicate loss of connectivity at some point or maybe a very stressed server.
For the DB access errors look at ME925744
. There seems to be an issue where if you used a simple password for your SQL Express access account it could create problems.
As good practice back up your datastore often.
Read the Citrix article number CTX677542
for some advanced farm maintenance and troubleshooting steps.