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Event ID: 4 Source: MSExchangeES

Source
Level
Description
An unexpected OS error occurred. Error returned was [5]. Access is denied.
Comments
 
As per Microsoft: "The Exchange service account does not have the required permissions. To resolve this problem, add the Exchange service account to the local Power Users group or to the local Administrators group on a member server. On a domain controller, add the account to the built-in Administrators group". See ME867641 for more details on this issue.
As per ME249046, "The Exchange Server service account does not have the required permissions".

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