SEP 11 creates this error when the virus definitions are corrupt. This error can occur with Event ID: 4 from SRTSP. The End Point Protection Manager Console does not report any issues with the SEP 11 client.
There is a manual procedure for rebuilding the virus definitions - See Symantec Doc ID 2007123111551948.
This error occurred with Symantec Antivirus Corporate version 10.1.4.4000 on the parent server itself (Small Business edition). The local AV engine was disabled as well although it was marked enabled and the service(s) were running. A red X appeared in the console for the server group and primary server but the logs did not reveal any threats, events, etc. explaining the problem.
We noticed that one of the clients, a laptop was listed a half a dozen times in the clients list. Since licensing is actually monitored on the small business edition of SAVCE, we found that these duplicate entries caused the license count to go over the allocation limit. We removed the duplicate client entries and refreshed the console. The licensing no longer showed over-usage and immediately following the local AV engine showed it was now enabled.
We resolved this problem by upgrading Symantec Antivirus to version 10.1.5.5000.