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Information Store (4300) First Storage Group: An attempt to open the file "C:\Program Files\Exchsrvr\mdbdata\E00.chk" for read/write access failed with system error 5 (0x00000005): "Access is denied.".
The open file operation will fail with error -1032 (0xfffffbf8).
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From a support forum: "In my case, this was caused by the antivirus installed on that system as it was causing the store to lock. I added the store in the A/V exclusion list and the problem is gone."
See also Error code 5 for suggestions about "Access denied" type of errors.
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