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Event ID: 4282 Source: MSExchangeMTA

An interoperability error occurred. Interface protocol was violated. Error code=8453, Control Block index=96 [POP4 MAIN BASE 1 18] (14)
According to Microsoft: "To resolve this issue, system time must be used consistently when the MTA calculates the time differences.". See ME152897, ME254818 and ME225345 for more details. MS Exchange 5.5 Service Pack 4 should resolve this issue.
When two Exchange Server computers are connected with an X.400 Connector, mail may queue up in both X.400 queues and not flow in either direction. The error occurs if the message transfer agent (MTA) becomes backed up while it is trying to deliver messages, and the transport connection is lost.

According to Microsoft: "This behavior can occur if you use Fully Qualified Domain Names (FQDN) or NetBIOS names to configure the connectors. To resolve this behavior, on both Exchange servers, configure the X.400 Connector to use the IP address of the remote MTA, and then restart both MTAs." See ME306959.

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